The question not answered is "what is the viologist's recipe for justifying a vaccine?"
Koches postulates:
But, what are Koches postulates?
Koch's postulates are a set of criteria established in the late 19th century to determine whether a specific microorganism is the cause of a particular disease. They were developed by German physician and microbiologist Robert Koch, along with his colleague Friedrich Loeffler. The four main postulates are:
1. The microorganism must be found in abundance in all organisms suffering from the disease, but should not be found in healthy organisms[1][2][3].
2. The microorganism must be isolated from a diseased organism and grown in pure culture[1][2][3].
3. The cultured microorganism should cause disease when introduced into a healthy organism[1][2][3].
4. The microorganism must be reisolated from the inoculated, diseased experimental host and identified as being identical to the original specific causative agent[1][2][3].
These postulates were groundbreaking in establishing a systematic approach to determining disease causation. They have been instrumental in identifying the causative agents of many infectious diseases, including tuberculosis and cholera[1].
However, it's important to note that Koch's postulates have limitations:
- They don't apply well to viruses, which can't be grown in pure culture outside of living cells[3].
- They don't account for asymptomatic carriers of pathogens[2].
- Some pathogens can cause multiple diseases, and some diseases can be caused by multiple pathogens[2].
- Not all healthy individuals are equally susceptible to disease[4].
Despite these limitations, Koch's postulates remain a fundamental concept in microbiology and epidemiology. They have been adapted and expanded over time to accommodate new discoveries in microbiology, including the development of molecular Koch's postulates for identifying virulence factors at the genetic level[3].
The question not answered is "what is the viologist's recipe for justifying a vaccine?"
Koches postulates:
But, what are Koches postulates?
Koch's postulates are a set of criteria established in the late 19th century to determine whether a specific microorganism is the cause of a particular disease. They were developed by German physician and microbiologist Robert Koch, along with his colleague Friedrich Loeffler. The four main postulates are:
1. The microorganism must be found in abundance in all organisms suffering from the disease, but should not be found in healthy organisms[1][2][3].
2. The microorganism must be isolated from a diseased organism and grown in pure culture[1][2][3].
3. The cultured microorganism should cause disease when introduced into a healthy organism[1][2][3].
4. The microorganism must be reisolated from the inoculated, diseased experimental host and identified as being identical to the original specific causative agent[1][2][3].
These postulates were groundbreaking in establishing a systematic approach to determining disease causation. They have been instrumental in identifying the causative agents of many infectious diseases, including tuberculosis and cholera[1].
However, it's important to note that Koch's postulates have limitations:
- They don't apply well to viruses, which can't be grown in pure culture outside of living cells[3].
- They don't account for asymptomatic carriers of pathogens[2].
- Some pathogens can cause multiple diseases, and some diseases can be caused by multiple pathogens[2].
- Not all healthy individuals are equally susceptible to disease[4].
Despite these limitations, Koch's postulates remain a fundamental concept in microbiology and epidemiology. They have been adapted and expanded over time to accommodate new discoveries in microbiology, including the development of molecular Koch's postulates for identifying virulence factors at the genetic level[3].
Citations:
[1] Koch's Postulates: Experiment, Steps, Limitations Explained - Vaia https://www.vaia.com/en-us/explanations/biology/communicable-diseases/kochs-postulates/
[2] Koch's postulates - Wikipedia https://en.wikipedia.org/wiki/Koch%27s_postulates
[3] 10.1D: Koch's Postulates - Biology LibreTexts https://bio.libretexts.org/Bookshelves/Microbiology/Microbiology_%28Boundless%29/10:_Epidemiology/10.01:_Principles_of_Epidemiology/10.1D:__Kochs_Postulates
[4] 1.6.5: Koch's Postulate - Biology LibreTexts https://bio.libretexts.org/Courses/Prince_Georges_Community_College/PGCC_Microbiology/01:_Introduction_to_Microbiology/1.06:_History_of_Microbiology/1.6.05:_Koch%27s_Postulate
[5] Koch's postulates Definition & Meaning | Merriam-Webster Medical https://www.merriam-webster.com/medical/Koch%27s%20postulates
[6] Medical Definition of Koch's postulates - RxList https://www.rxlist.com/kochs_postulates/definition.htm
[7] Koch's Postulates and Infectious Proteins - PMC - NCBI https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544537/
[8] Integration of microbiome and Koch's postulates to reveal multiple ... https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-023-01570-6
And non of the 224 FOI responses showed isolation or purification of any virus.